Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 29, Issue 5, Pages 886-890Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2009.16
Keywords
cardiopulmonary bypass; deep hypothermia; gene expression; SUMO conjugation
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Funding
- Department of Anesthesiology, Duke University Medical Center
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Various cardiovascular operations are performed during conditions of deep hypothermic circulatory arrest. Here we investigated the effects of deep hypothermia on the small ubiquitin-like modifier (SUMO) conjugation pathway using a clinically relevant animal model of deep hypothermic cardiopulmonary bypass (DHCPB). Deep hypothermic cardiopulmonary bypass induced a marked activation of the SUMO conjugation pathway and triggered a nuclear translocation of SUMO2/3-conjugated proteins. Furthermore, DHCBP significantly modified gene expression. Activation of the SUMO conjugation pathway is believed to protect neurons from damage caused by low blood flow. This pathway may, therefore, play a key role in defining the outcome of cells exposed to DHCPB. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 886-890; doi:10.1038/jcbfm.2009.16; published online 25 February 2009
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