Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 29, Issue 5, Pages 965-975Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2009.22
Keywords
cerebral blood flow; cerebral contusions; cerebral metabolism; magnetic resonance imaging; positron emission tomography; traumatic brain injury
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Funding
- Medical Research Council
- Royal College of Anaesthetists/British Journal of Anaesthesia
- Academy of Medical Sciences/Health Foundation
- Cambridge NIHR Biomedical Research Centre
- Spanish health ministry [CP07/00048]
- MRC [G9439390, G0001237, G0600986] Funding Source: UKRI
- Medical Research Council [G0001237, G9439390, G0600986] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
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We defined lesion and structurally normal regions using magnetic resonance imaging at follow-up in patients recovering from head injury. Early metabolic characteristics in these regions of interest (ROIs) were compared with physiology in healthy volunteers. Fourteen patients with severe head injury had positron emission tomography within 72 h, and magnetic resonance imaging at 3 to 18 months after injury. Cerebral blood flow (CBF), oxygen utilization (CMRO2), and oxygen extraction fraction (OEF) were all lower in lesion ROIs, compared with nonlesion and control ROIs (P < 0.001); however, there was substantial overlap in physiology. Control ROIs showed close coupling among CBF, blood volume (CBV), and CMRO2, whereas relationships within lesion and nonlesion ROIs were abnormal. The relationship between CBF and CMRO2 generally remained coupled but the slope was reduced; that for CBF and OEF was variable; whereas that between CBF and CBV was highly variable. There was considerable heterogeneity between and within patients. Although irreversibly damaged tissue is characterized by marked derangements in physiology, a more detailed analysis shows acute changes in physiology and physiologic relationships within regions of the brain that appear structurally normal at follow-up. Such pathophysiological derangements may result in selective neuronal loss and impact on functional outcome. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 965-975; doi:10.1038/jcbfm.2009.22; published online 18 March 2009
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