Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 29, Issue 2, Pages 221-223Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2008.101
Keywords
animal models; drug trials; experimental; outcomes; preventing bias; translational research
Categories
Funding
- NINDS NIH HHS [R01 NS046072-08, R01 NS046072] Funding Source: Medline
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As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
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