A parametric study on the processing and physical characterization of PLGA 50/50 bioscaffolds

The ability to control the characteristics of scaffolds is important such that scaffolds can be fine tuned for specific applications. In this study, the effects of processing parameters on cell morphology and mechanical properties of PLGA 50/50 bioscaffolds for tissue engineering applications were investigated. Specifically, the effects of salt particle sizes and salt-to-polymer mass ratios on the scaffold relative density, average pore size and density, open-cell porosity, and mechanical properties were examined. The PLGA samples were processed using a salt leaching technique in a batch-foaming setup. Experiments showed that pore size and density were dependent on the salt particle size used, and that as the salt-to-polymer mass ratio increased, the porosity increased while the relative density decreased. The results showed that by varying the salt parameters during fabrication, the scaffold characteristics and morphology can be controlled.