Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 2, Pages 1008-1015Publisher
WILEY
DOI: 10.1002/jcp.27090
Keywords
BMSCs; melatonin; signaling pathways; stem cell
Categories
Funding
- China Postdoctoral Science Foundation [2018T111085]
- Shaanxi State Ministry of Health [2016D044]
- Shaanxi Postdoctoral Science Foundation [2017BSHQYXMZZ14]
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Melatonin's therapeutic potential has been highly underestimated because its biological functional roles are diverse and relevant mechanisms are complicated. Among the numerous biological activities of melatonin, its regulatory effects on pluripotent mesenchymal stem cells (MSCs), which are found in bone marrow stem cells (BMSCs) and adipose tissue (AD-MSC), have been recently proposed, which has received increasingly more attention in recent studies. Moreover, receptor-dependent and receptor-independent responses to melatonin are identified to occur in these cells by regulating signaling pathways, which drive the commitment and differentiation of MSCs into osteogenic, chondrogenic, or adipogenic lineages. Therefore, the aim of our current review is to summarize the evidence related to the utility of melatonin as a regulatory agent by focusing on its relationship with the differentiation of MSCs. In particular, we aimed to review its roles in promoting osteogenic and chondrogenic differentiation and the relevant signaling cascades involved. Also, the roles that melatonin and, particularly, its receptors play in these processes are highlighted.
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