4.7 Article

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-κB signaling pathways

Journal

JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 4, Pages 4267-4276

Publisher

WILEY
DOI: 10.1002/jcp.27195

Keywords

asiaticoside; NF-kappa B; NFAT pathway; osteoclast; RANKL

Funding

  1. Guangdong Medical Science and Technology Research Foundation [A2016580]
  2. Australian Health and Medical Research Council [APP1127396, APP1107828, APP1127156]
  3. National Natural Science Foundation of China [81573996, 81473697]

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Identification of natural compounds that inhibit osteoclastogenesis will facilitate the development of antiresorptive treatment of osteolytic bone diseases. Asiaticoside is a triterpenoid derivative isolated from Centella asiatica, which exhibits varying biological effects like angiogenesis, anti-inflammation, wound healing, and osteogenic differentiation. However, its role in osteoclastogenesis remains unknown. Here, we show that Asiaticoside can suppress RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner. Asiaticoside attenuated the expression of osteoclast marker genes including Ctsk, Atp6v0d2, Nfatc1, Acp5, and Dc-stamp. Furthermore, Asiaticoside inhibited RANKL-mediated NF-B and NFATc1 activities, and RANKL-induced calcium oscillation. Collectively, this study demonstrates that Asiaticoside inhibited osteoclast formation and function through attenuating RANKL-induced key signaling pathways, which may indicate that Asiaticoside is a potential antiresorptive agent against osteoclast-related osteolytic bone diseases.

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