Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 233, Issue 12, Pages 9110-9120Publisher
WILEY
DOI: 10.1002/jcp.26951
Keywords
cancer; Ebp1; ErbB3
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Funding
- National Foundation for Science and Technology Development, Vietnam
- Department of Science and Technology of Ho Chi Minh City, Vietnam
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ErbB3, a member of the epidermal growth factor receptorfamily, reportedly plays an essential role in the regulation of cancer progression and therapeutic resistance. Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3, plays an important regulatory role in the expression and function of ErbB3, but there is no agreement as to whether Ebp1 also has an ErbB3-independent function in cancer and how it might contribute to tumorigenesis. In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth.
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