Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 228, Issue 11, Pages 2232-2242Publisher
WILEY
DOI: 10.1002/jcp.24396
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [PO1AR049920]
- Department of Orthopaedic Surgery at Boston University School of Medicine
- Boston University School of Medicine
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Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an endochondral process and marrow ablation that proceeds by only an intramembranous process. Both Runx2 and Runx3 mRNAs were differentially up regulated during fracture healing. In contrast, only Runx2 showed increased expression after marrow ablation. During fracture healing, Runx3 was expressed earlier than Runx2, was concurrent with the period of chondrogenesis, and coincident with maximal aggrecan expression a protein associated with proliferating and permanent cartilage. Immunohistological analysis showed Runx3 protein was also expressed by chondrocytes in vivo. In contrast, Runx2 was expressed later during chondrocyte hypertrophy, and primary bone formation.
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