Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 227, Issue 4, Pages 1569-1576Publisher
WILEY-BLACKWELL
DOI: 10.1002/jcp.22871
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Funding
- JSPS KAKENHI [21209962, 23500773, 23650402]
- Grants-in-Aid for Scientific Research [23650402, 23500773] Funding Source: KAKEN
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Mammalian target of rapamycin (mTOR) pathway positively regulates the cell growth through ribosome biogenesis in many cell type. In general, myostatin is understood to repress skeletal muscle hypertrophy through inhibition of mTOR pathway and myogenesis. However, these relationships have not been clarified in skeletal muscle undergoing atrophy. Here, we observed a significant decrease of skeletal muscle mass at 2 weeks after denervation. Unexpectedly, however, mTOR pathway and the expression of genes related to myogenesis were markedly increased, and that of myostatin was decreased. However, de novo ribosomal RNA synthesis and the levels of ribosomal RNAs were dramatically decreased in denervated muscle. These results indicate that ribosome biogenesis is strongly controlled by factors other than the mTOR pathway in denervated atrophic muscle. Finally, we assessed rRNA transcription factors expression and observed that TAFIa was the only factor decreased. TAFIa might be a one of the limiting factor for rRNA synthesis in denervated muscle. J. Cell. Physiol. 227: 1569-1576, 2012. (C) 2011 Wiley Periodicals, Inc.
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