Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 227, Issue 3, Pages 1235-1241Publisher
WILEY
DOI: 10.1002/jcp.22899
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Funding
- East Carolina University
- East-West Collaboration Research Awards
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The Ras-ERK/MAP (Mitogen-Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras-ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis. Although the regulation of the Ras-ERK/MAPK signaling pathway by post-translational modification has been well elucidated, post-transcriptional regulations of this pathway are beginning to emerge in invertebrates and this work is extended to humans. In this review, we describe the conserved regulation of Ras-ERK/MAPK signaling by RNA-binding proteins (PUF, KH-domain, HuR, and LARP) and microRNAs (let-7 family miRNAs) and important implications for human diseases including cancers. J. Cell. Physiol. 227: 12351241, 2012. (C) 2011 Wiley Periodicals, Inc.
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