Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 225, Issue 2, Pages 321-325Publisher
WILEY
DOI: 10.1002/jcp.22281
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Funding
- NHLBI NIH HHS [U01 HL099776, K08 HL081086] Funding Source: Medline
- NIH HHS [DP2 OD004411] Funding Source: Medline
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The mammalian heart lacks the capacity to replace the large numbers of cardiomyocytes lost due to cardiac injury. Several different cell-based routes to myocardial regeneration have been explored, including transplantation of cardiac progenitors and cardiomyocytes into injured myocardium. As seen with cell-based therapies in other solid organ systems, inherent limitations, such as host immune response, cell death and long-term graft instability have hampered meaningful cardiac regeneration. An understanding of the cell biology of cardiac progenitors, including their developmental origin, lineage markers, renewal pathways, differentiation triggers, microenvironmental niche, and mechanisms of homing and migration to the site of injury, will enable further refinement of therapeutic strategies to enhance clinically meaningful cardiac repair. J. Cell. Physiol. 225: 321-325, 2010. (C) 2010 Wiley-Liss, Inc.
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