Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 225, Issue 3, Pages 631-637Publisher
WILEY
DOI: 10.1002/jcp.22322
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Funding
- Niels Stensen Foundation, The Netherlands (NSF)
- American Heart Association [SDG0735602T]
- National Institute of Health [1K08 CA 129204, DK 55001, CA 125550]
- Division of Matrix Biology at the Beth Israel Deaconess Medical Center
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Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial-mesenchynmal transition or from bone marrow-derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis. NB. The information given is correct. J. Cell. Physiol. 225: 631-637, 2010. (C) 2010 Wiley-Liss, Inc.
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