Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 218, Issue 1, Pages 13-21Publisher
WILEY
DOI: 10.1002/jcp.21567
Keywords
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Funding
- National Institute of Health [R01 CAI 09389]
- Leukemia Lymphoma CA [109389]
- Leukemia and Lymphoma Society [6028-07]
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A critical regulator of the apoptotic machinery is the Bcl-2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti-cancer drugs and treatment regimen are found to over express these Bcl-2 proteins such as Bcl-2, Bcl-X-L, Mcl-1, Bcl-w, and AI/Bfl1. In recent years there has been an exponential growth in the identification as well as synthesis of non-peptidic cell permeable small-molecule inhibitors (SMIs) of protein-protein interaction. The focus of this article is on inhibitors of anti-apoptotic protein Bcl-2. This review summarizes an up to date knowledge of the available SMIs their mode of action as well as their current status in preclinical as well as clinical development.
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