Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 215, Issue 1, Pages 77-81Publisher
WILEY-LISS
DOI: 10.1002/jcp.21289
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Funding
- MRC [G0501019] Funding Source: UKRI
- Medical Research Council [G0501019] Funding Source: Medline
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The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activity.
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