Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 4, Pages 4883-4891Publisher
WILEY
DOI: 10.1002/jcb.27762
Keywords
apoptosis; human brain microvascular endothelial cells; oxygen-glucose deprivation; tangeretin
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Funding
- Project of Health and Family Planning Commission of Henan Province, China [201403145]
- Project of Key Science and Technology Program of Henan Province, China [182102311242]
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Tangeretin, a citrus flavonoid extracted from the peel of citrus fruits, was reported to possess antiasthmatic, antioxidant, anti-inflammatory, and neuroprotective properties. However, the effect of tangeretin on human brain microvascular endothelial cells (HBMECs) has not been examined. This study was designed to investigate the protective effects of tangeretin on oxygen-glucose deprivation (OGD)-induced injury of HBMECs, and explore the underlying mechanisms. Our results showed that tangeretin improved HBMECs viability in response to OGD. In addition, tangeretin was able to increase the activity of superoxide dismutase and decrease the levels of reactive oxygen species and malondialdehyde (MDA), as well as ameliorate cell apoptosis in OGD-stimulated HBMECs. Mechanistic studies showed that tangeretin prevented the activation of JNK signaling pathway in OGD-stimulated HBMECs. Taken together, our current study demonstrated that tangeretin could ameliorate OGD-induced HBMECs injury through the JNK signaling pathway. Thus, tangeretin might be used as a therapeutic strategy for ischemia-reperfusion brain injury and related diseases.
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