Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 119, Issue 11, Pages 8713-8722Publisher
WILEY
DOI: 10.1002/jcb.27192
Keywords
antiplatelet activity; curcumin; platelet activation; platelet adhesion; platelet aggregation
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Curcumin, the main ingredient of Curcuma longa L., has been used as a spice and as a herbal medicine with different therapeutic characteristics for centuries in Asian countries. This phytochemical has been shown to possess beneficial antiplatelet activity that has introduced it as a promising candidate for the treatment of thromboembolism, atherothrombosis, and inflammatory diseases. Platelet dysfunction under different circumstances may lead to cardiovascular disease, and curcumin has been shown to have beneficial effects on platelet dysfunction in several studies. Therefore, this narrative review is aimed to summarize available evidence on the antiplatelet activity of curcumin and related molecular mechanisms for this activity.
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