Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 116, Issue 2, Pages 212-217Publisher
WILEY
DOI: 10.1002/jcb.24959
Keywords
EPIGENETICS; RADIATION; METHYLATION; AZACYTIDINE; DECITABINE; ZEBULARINE
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DNA methylation has been studied with regard to chemotherapeutics for a number of years. The radiation field has just begun to look at this in the context of radiotherapy or radiation exposure. So far, the data suggest that radiation induces epigenetic reprogramming which indicates a purposeful response that influences the cell fate or alters the response to future exposure. Further studies may result in discovery of biomarkers for radiotherapy outcome or prediction of the degree of radiation resistance. Past and ongoing development of DNMT1 inhibitors that lead to DNA hypomethylation appear to sensitize many tumor types to radiation and may be an area with long term clinical implications. (C) 2014 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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