Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 115, Issue 8, Pages 1351-1361Publisher
WILEY-BLACKWELL
DOI: 10.1002/jcb.24803
Keywords
Wnt; beta-CATENIN; NUCLEAR TRANSLOCATION/LOCALIZATION; LEUKEMIA; CANCER
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Funding
- Medical Research Council UK
- Leukaemia and Lymphoma Research UK
- Cardiff University
- Cancer Research UK [11975] Funding Source: researchfish
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The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, beta-catenin. In particular, the nuclear localization of beta-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling beta-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of beta-catenin and how they are relevant to cancer. (C) 2014 Wiley Periodicals, Inc.
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