Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 114, Issue 6, Pages 1223-1229Publisher
WILEY
DOI: 10.1002/jcb.24467
Keywords
ATDC5; CHONDROGENESIS; ENDOCHONDRAL OSSIFICATION
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Funding
- National High Technology Research and Development Program of China [2012CB619100, 2011CB606204]
- Key Program for National Natural Science Foundation of China [50830101]
- Guangdong Natural Science Foundation [S2011040000208]
- Fundamental Research Funds for the Central Universities [2011ZM0010]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0919]
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The ATDC5 cell line is derived from mouse teratocarcinoma cells and characterized as a chondrogenic cell line which goes through a sequential process analogy to chondrocyte differentiation. Thus, it is regarded as a promising in vitro model to study the factors that influence cell behaviors during chondrogenesis. It also provides insights in exploring signaling pathways related to skeletal development as well as interactions with innovative materials. To date, over 200 studies have utilized ATDC5 to obtain lots of significant findings. In this review, we summarized the literature of ATDC5 related studies and emphasized the application of ATDC5 in chondrogenesis. In addition, the general introduction of ATDC5 including its derivation and characterization is covered in this article. J. Cell. Biochem. 114: 12231229, 2013. (c) 2012 Wiley Periodicals, Inc.
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