Journal
NEUROIMAGE
Volume 107, Issue -, Pages 229-241Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2014.10.039
Keywords
Functional MRI; Brain mapping; Optogenetics; Hippocampus; Seizure
Funding
- NIH/NIBIB R00 Award [4R00EB008738]
- Okawa Foundation Research Grant Award
- NIH Director's New Innovator Award [1DP2OD007265]
- NSF CAREER Award [1056008]
- Alfred P. Sloan Research Fellowship
- James and Carrie Anderson Fund for Epilepsy Research
- Susan Horngren and Littlefield Funds
- Bio-X Bioengineering Graduate Fellowship
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1056008] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1460400] Funding Source: National Science Foundation
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Although the connectivity of hippocampal circuits has been extensively studied, the way in which these connections give rise to large-scale dynamic network activity remains unknown. Here, we used optogenetic fMRI to visualize the brain network dynamics evoked by different frequencies of stimulation of two distinct neuronal populations within dorsal and intermediate hippocampus. Stimulation of excitatory cells in intermediate hippocampus caused widespread cortical and subcortical recruitment at high frequencies, whereas stimulation in dorsal hippocampus led to activity primarily restricted to hippocampus across all frequencies tested. Sustained hippocampal responses evoked during high-frequency stimulation of either location predicted seizure-like after discharges in video-EEG experiments, while the widespread activation evoked by high-frequency stimulation of intermediate hippocampus predicted behavioral seizures. A negative BOLD signal observed in dentate gyrus during dorsal, but not intermediate, hippocampus stimulation is proposed to underlie the mechanism for these differences. Collectively, our results provide insight into the dynamic function of hippocampal networks and their role in seizures. (C) 2014 Elsevier Inc. All rights reserved.
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