Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 113, Issue 6, Pages 1926-1935Publisher
WILEY
DOI: 10.1002/jcb.24061
Keywords
ADIPOGENESIS; HEME; OXIDATIVE STRESS; TEMPOL; 3T3L1
Categories
Funding
- National Institutes of Health [DK068134, HL55601, HL34300]
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Patho-physiological conditions with high oxidative stress, such as conditions associated with increased denatured heme-proteins, are associated with enhanced adipogenic response. This effect predominantly manifests as adipocyte hypertrophy characterized by dysfunctional, pro-inflammatory adipocytes exhibiting reduced expression of anti-inflammatory hormone, adiponectin. To understand how increased levels of cellular heme, a pro-oxidant molecule, modulates adipogenesis; the following study was designed to evaluate effects of heme on adipogenesis in human mesenchymal stem cells (hMSCs) and mouse pre-adipocytes (3T3L1). Experiments were conducted in the absence and in the presence of a superoxide dismutase (SOD) mimetic (tempol, 100 mu M). Heme (10 mu M) increased (P?
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