Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 113, Issue 3, Pages 956-966Publisher
WILEY
DOI: 10.1002/jcb.23425
Keywords
FGF1; NONCLASSICAL SECRETION; PHOSPHATIDYLSERINE EXPOSURE; BLEBBING; PLSCR1
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Funding
- Maine Cancer Foundation
- NIH [P20 RR15555, L35627, HL036946, HL063819]
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The mechanisms of nonclassical export of signal peptide-less proteins remain insufficiently understood. Here, we demonstrate that stress-induced unconventional export of FGF1, a potent and ubiquitously expressed mitogenic and proangiogenic protein, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine (PS). In addition, we found that the differentiation of promonocytic cells results in massive FGF1 release, which also correlates with membrane blebbing and exposure of PS. These findings indicate that the externalization of acidic phospholipids could be used as a pharmacological target to regulate the availability of FGF1 in the organism. J. Cell. Biochem. 113: 956966, 2012. (C) 2011 Wiley Periodicals, Inc.
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