Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 113, Issue 7, Pages 2201-2207Publisher
WILEY
DOI: 10.1002/jcb.24116
Keywords
Arf; Arl; CILIA; CILIOPATHIES
Categories
Funding
- NIH/NIDDK [RO1-DK090038, P30-DK084567-03]
- PKD Foundation [04YI09b]
- Mayo translation center for PKD
- Mayo Clinic Center for Cell Signaling in Gastroenterology
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Once overlooked as an evolutionary vestige, the primary cilium has recently been the focus of intensive studies. Mounting data show that this organelle is a hub for various signaling pathways during vertebrate embryonic development and pattern formation. However, how cilia form and how cilia execute the sensory function still remain poorly understood. Cilia dysfunction is correlated with a wide spectrum of human diseases, now termed ciliopathies. Various small GTPases, including the members in Arf/Arl, Rab, and Ran subfamilies, have been implicated in cilia formation and/or function. Here we review and discuss the role of one particular group of small GTPase, Arf/Arl, in the context of cilia and ciliopathy. J. Cell. Biochem. 113: 22012207, 2012. (c) 2012 Wiley Periodicals, Inc.
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