Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 113, Issue 7, Pages 2208-2216Publisher
WILEY
DOI: 10.1002/jcb.24120
Keywords
IN VIVO CHEMICAL SCREENING; MECHANISM OF ACTION; ANIMAL MODEL
Categories
Funding
- U.S. National Institutes of Health [R01 CA140188, K01 AG031300]
- Massachusetts General Hospital
Ask authors/readers for more resources
The number of possible small organic molecules of different structure is virtually limitless. One of the main goals of chemical biologists is to identify, from this chemical space, entities that affect biological processes or systems in a specific manner. This can lead to a better understanding of the regulation and components of various biological machineries, as well as provide insights into efficacious therapeutic targets and drug candidates. However, the challenges confronting chemical biologists are multiple. How do we efficiently identify compounds that possess desirable activities without unwanted off-target effects? Once a candidate compound has been found, how do we determine its mode of action? In this Prospects piece, we call attention to recent studies using embryonic and larval zebrafish to illustrate the breadth and depth of questions in chemical biology that may be addressed using this model, and hope that they can serve as catalysts for future investigational ideas. J. Cell. Biochem. 113: 22082216, 2012. (c) 2012 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available