Related references
Note: Only part of the references are listed.Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors
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A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms
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Adam M. Gilbert et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
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PROTEIN SCIENCE (2008)
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
Kazunari Fushimi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
ADAMTS-5: The story so far
Amanda J. Fosang et al.
EUROPEAN CELLS & MATERIALS (2008)
Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aaarecan in a porcine chondrocyte culture system
Alison J. Powell et al.
ARTHRITIS AND RHEUMATISM (2007)
Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions
Pooi-See Chan et al.
AMERICAN JOURNAL OF VETERINARY RESEARCH (2007)
Proteolytic activities of human ADAMTS-5 - Comparative studies with ADAMTS-4
Christi Gendron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The futility of current approaches to chondroprotection
David T. Felson et al.
ARTHRITIS AND RHEUMATISM (2007)
5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
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ARTHRITIS AND RHEUMATISM (2007)
Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13
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MATRIX BIOLOGY (2006)
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein
Chuan-ju Liu et al.
FASEB JOURNAL (2006)
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5,-9,-16 and-18
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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
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ARTHRITIS RESEARCH & THERAPY (2006)
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
CB Little et al.
ARTHRITIS AND RHEUMATISM (2005)
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
SS Glasson et al.
NATURE (2005)
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
H Stanton et al.
NATURE (2005)
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S Porter et al.
BIOCHEMICAL JOURNAL (2005)
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
DA Young et al.
ARTHRITIS RESEARCH & THERAPY (2005)
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing
M Kashiwagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice
SS Glasson et al.
ARTHRITIS AND RHEUMATISM (2004)
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
K Kuno et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
LA Collins-Racie et al.
MATRIX BIOLOGY (2004)
Expression profiling of metalloproteinases and their inhibitors in cartilage
L Kevorkian et al.
ARTHRITIS AND RHEUMATISM (2004)
Variations in aggrecan structure modulate its susceptibility to aggrecanases
PJ Roughley et al.
BIOCHEMICAL JOURNAL (2003)
Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage
S Makihira et al.
ENDOCRINOLOGY (2003)
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
RPT Somerville et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Aggrecanases and cartilage matrix degradation
H Nagase et al.
ARTHRITIS RESEARCH & THERAPY (2003)
Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein
MA Pratta et al.
ARTHRITIS AND RHEUMATISM (2003)
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
CR Flannery et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage
AM Malfait et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
被撤回的出版物: Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids (Retracted Article. See vol 54, pg 2933, 2006)
CL Curtis et al.
ARTHRITIS AND RHEUMATISM (2002)
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M - A time-course study using real-time quantitative reverse transcription-polymerase chain reaction
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ARTHRITIS AND RHEUMATISM (2002)
Activation of the proteolytic activity of ADAMTS4 (Aggrecanase-1) by C-terminal truncation
G Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression and regulation of aggrecanase in arthritis:: The role of TGF-β
Y Yamanishi et al.
JOURNAL OF IMMUNOLOGY (2002)
Potent P1′ biphenylmethyl substituted aggrecanase inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Leech thrombin inhibitors
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CURRENT PHARMACEUTICAL DESIGN (2002)
Metalloproteases and inhibitors in arthritic diseases
J Martel-Pelletier et al.
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Design and synthesis of a series of (2R)-N4-hydroxy-2-(3-hydroxybenzyl)-N1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors
WQ Yao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
MD Tortorella et al.
OSTEOARTHRITIS AND CARTILAGE (2001)
Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase
MA Pratta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site.: Efficient aggrecanase catabolism may depend on multiple substrate interactions
C Hörber et al.
MATRIX BIOLOGY (2000)
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage
M Tortorella et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
K Kuno et al.
FEBS LETTERS (2000)
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member
RT Matthews et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)
MD Tortorella et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)