Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 112, Issue 11, Pages 3073-3078Publisher
WILEY
DOI: 10.1002/jcb.23250
Keywords
MSCs; SECRETORY FACTORS; ADULT PROGENITOR CELLS
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Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases. J. Cell. Biochem. 112: 3073-3078, 2011. (C) 2011 Wiley Periodicals, Inc.
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