Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 112, Issue 12, Pages 3755-3761Publisher
WILEY
DOI: 10.1002/jcb.23315
Keywords
SIRT1; SIRT5; CALORIC RESTRICTION; BEHAVIORAL PERFORMANCE
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Funding
- Foundation for Distinguished Young Talents in Higher Education of Guangdong, China [LYM08057]
- Medical Scientific Research Foundation of Guangdong Province, China [B2008140]
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To investigate the effects of calorie restriction (CR) on behavioral performance and expression of SIRT1 and SIRT5 in rat cerebral tissues. Beginning at 18 months of age, 60 rats were randomly divided into a CR group (n = 30) and a group that remained fed ad libitum (AL; n = 30). CR rats were restricted to a diet of 60% of their daily food consumption. After 6 months of CR, CR rats displayed a maximum 50% reduction in escape latency (AL 20 +/- 0.3 s vs. CR 10 +/- 0.2 s) and a 3.2 s decrease in time and distance to target when evaluated in Morris water maze tests. The levels of SIRT1 and SIRT5 protein in cerebral tissues of CR rats were elevated compared to AL rats (P < 0.05). CR retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats. J. Cell. Biochem. 112: 3755-3761, 2011. (C) 2011 Wiley Periodicals, Inc.
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