Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 112, Issue 1, Pages 89-97Publisher
WILEY
DOI: 10.1002/jcb.22800
Keywords
MANGIFERIN; OSTEOCLASTOGENESIS; BONE RESORPTION; RANKL; NF-kappa B
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Funding
- National Health and Medical Research Council of Australia
- Arthritis Foundation of Western Australia
- Sir Charles Gairdner Hospital Research Fund, Western Australia
- Sir Charles Gairdner Hospital Foundation, Western Australia
- National Health and Medical Research Council of Australia/Osteoporosis Australia (NHMRC/OA)
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Osteolytic bone diseases such as osteoporosis have a common pathological feature in which osteoclastic bone resorption outstrips bone synthesis. Osteoclast formation and activation are regulated by receptor activator of nuclear factor kappa B ligand (RANKL). The induction of RANKL-signaling pathways occurs following the interaction of RANKL to its cognate receptor, RANK. This specific binding drives the activation of downstream signaling pathways; which ultimately induce the formation and activation of osteoclasts. In this study, we showed that a natural immunomodulator, mangiferin, inhibits osteoclast formation and bone resorption by attenuating RANKL-induced signaling. Mangiferin diminished the expression of osteoclast marker genes, including cathepsin K, calcitonin receptor, DC-STAMP, and V-ATPase d2. Mechanistic studies revealed that mangiferin inhibits RANKL-induced activation of NF-kappa B, concomitant with the inhibition of I kappa B-alpha degradation, and p65 nuclear translocation. In addition, mangiferin also exhibited an inhibitory effect on RANKL-induced ERK phosphorylation. Collectively, our data demonstrates that mangiferin exhibits anti-resorptive properties, suggesting the potential application of mangiferin for the treatment and prevention of bone diseases involving excessive osteoclastic bone resorption. J. Cell. Biochem. 112: 89-97, 2011. (C) 2010 Wiley-Liss, Inc.
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