4.6 Article

Antagonistic Interplay Between Mechanical Forces and Glucocorticoids in Bone: A Tale of Kinases

Journal

JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 111, Issue 1, Pages 1-6

Publisher

WILEY
DOI: 10.1002/jcb.22660

Keywords

MECHANICAL FORCES; GLUCOCORTICOIDS; FAR; Pyk2; OSTEOCYTES; BONE FORMATION; Wnt PATHWAY

Funding

  1. NCI NIH HHS [R01 CA209882] Funding Source: Medline
  2. NIAMS NIH HHS [R01 AR059357, K02 AR002127] Funding Source: Medline
  3. NIDDK NIH HHS [R01 DK076007] Funding Source: Medline

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The contrasting actions of mechanical forces and glucocorticoids (GC) on bone have been long recognized However, the cellular and molecular mechanisms by which these stimuli impact the skeleton remain only partially known Recent evidence gained from studies on bone cell apoptosis has revealed that mechanical forces and GC exhibit converse effects on osteocyte and osteoblast survival resulting from divergent actions on the focal adhesion kinases FAK and Pyk2, molecules that regulate integrin-dependent interactions between bone cells and the extracellular matrix (ECM) This prospect reviews these findings and poses the possibility that similar opposing effects on kinase signaling are responsible for other actions of mechanical forces and GC on the skeleton, in particular on bone formation and the Wnt signaling pathway J. Cell Biochem. 111. 1-6, 2010. (C) 2010 Wiley-Liss. Inc

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