Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 110, Issue 2, Pages 321-332Publisher
WILEY
DOI: 10.1002/jcb.22540
Keywords
CANNABINOID; GASTRIC CANCER; PROLIFERATION; INVASION; APOPTOSIS
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Funding
- Korean Government [KRF-2008-331-E00102]
- Catholic Cancer Center of Korea
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Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy. J. Cell. Biochem. 110: 321-332, 2010. (C) 2010 Wiley-Liss, Inc.
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