Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 106, Issue 6, Pages 1031-1040Publisher
WILEY
DOI: 10.1002/jcb.22081
Keywords
CHOLESTEROL; STRESS FIBER; RHO; ROCK; SRC; CAVEOLIN-1
Categories
Funding
- National Institutes of Health [CA101046]
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Dynamic interactions between cellular membranes and the cytoskeleton are known to play major roles in many cellular responses to environmental cues. External signals resulting in proliferation, differentiation, polarization, and motility must be translated from chemical signals into changes of state, often involving the cytoskeleton-dependent altering of cell shape and redistribution of molecules. Cholesterol, a critical component of eukaryotic cell membranes, performs vital roles in regulating membrane dynamics and function. Here we demonstrate, using mesenchymal and epithelial cell lines, that depletion of membrane cholesterol results in Src kinase-mediated Rho activation and caveolin phosphorylation, which together collaborate to form stress fibers. These results demonstrate that cholesterol is a critical regulator of membrane-cytoskeletal dynamics and suggest that altered cholesterol concentrations may result in dramatic changes in cellular responses mediated by the cytoskeleton. J. Cell. Biochem. 106: 1031-1040, 2009. (c) 2009 Wiley-Liss, Inc.
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