Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 108, Issue 1, Pages 117-124Publisher
WILEY
DOI: 10.1002/jcb.22233
Keywords
GINSENOSIDE Rg1; HYPOXIA/REOXYGENATION; ANTIOXIDANT; REACTIVE OXYGEN SPECIES; Ca2+ OVERLOAD
Categories
Funding
- State 863 High Technology Research and Development Project of China [2003AA2Z2042]
- National Natural Sciences Foundation of China [3027 1617]
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Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatment with ginsenoside Rg1 (60-120 mu M) reduced lactate dehydrogenase release and increased cell viability in a dose-dependent manner. Fluorescence analysis demonstrated ginsenoside Rg1 reduced intracellular ROS and suppressed the intracellular [Ca2+] level. Cell lysate detected an increase of T-SOD, CAT, and GSH levels. The myocardial protection of ginsenoside Rg1 during H/R is partially due to its antioxidative effect and intracellular calcium homeostasis. J. Cell. Biochem. 108: 117-124, 2009. (C) 2009 Wiley-Liss, Inc.
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