Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 104, Issue 1, Pages 15-26Publisher
WILEY
DOI: 10.1002/jcb.21599
Keywords
tanshinone IIA; Salviae Miltiorrahizae (Salvia miltiorrhiza Bunge); matrix metalloproteinase-9; human aortic smooth muscle cells; tumor necrosis factor-alpha
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Funding
- Korea Health 21 RD Project
- Ministry of Health & Welfare, Republic of Korea
- Korea Biotech RD Group (KBRDG)
- Ministry of Science and Technology of Korean Government
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Smooth muscle cell (SMC) migration plays an important role in normal angiogenesis and is relevant to disease-related vascular remodeling in conditions such as brain arteriovenous malformations, pulmonary hypertension, arteriosclerosis, and restenosis after angioplasty. In this present study, we showed that tanshinone IIA, the major liqid-soluble pharmacological constituent of Salivia miltiorrhiza BUNGE, inhibits human aortic smooth muscle cell (HASMC) migration and MMP-9 activity. Tanshinone IIA significantly inhibited IkB alpha phosphorylation and p65 nuclear translocation through inhibition of AKT phosphorylation. Tanshinone IIA inhibited TNF-alpha-induced ERK and c-jun phosphorylation, but not other MAPKs such as JNK and p38. Tanshinone IIA also inhibited NF-kappa B and AP-1 DNA-binding. Moreover, tanshinone IIA inhibited the migration of HASMC migration and may offer a therapeutic approach to block HASMC migration. J. Cell. Biochem.
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