Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 103, Issue 2, Pages 383-392Publisher
WILEY
DOI: 10.1002/jcb.21425
Keywords
bone; Runx2; TIEG; estrogen; TGF beta; osteoblast; osteoclast
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Funding
- NHLBI NIH HHS [R01 HL085591, R01 HL085591-02, R01 HL085591-01A1] Funding Source: Medline
- NIAMS NIH HHS [AR52004, R01 AR052004] Funding Source: Medline
- NIA NIH HHS [AG04875, P01 AG004875] Funding Source: Medline
- NIDCR NIH HHS [R01 DE-14036, R01 DE014036] Funding Source: Medline
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It is well established that E-2 and TGF beta have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E2 and TGF beta continue to be elucidated. In this prospectus, we present known and potential roles of TIEG, Runx2, and other transcription factors as important mediators of signaling between these two pathways.
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