Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 104, Issue 3, Pages 934-941Publisher
WILEY-LISS
DOI: 10.1002/jcb.21675
Keywords
cell migration; MMP; TGF-beta1; JNK
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The importance of expression of matrix metalloproteinase (MMP) in keratinocyte migration is well established, but its role remains unclear. Here we investigated the function of MMP-14 in TGF-beta 1-induced keratinocyte migration. TGF-beta 1 stimulated cell migration and the expression of MMP-2, -9 in HaCaT human keratinocyte cells. When we lowered MMP-14 mRNA with siRNA, cell migration, and MMP-9 expression decreased. Furthermore, the MMP-14 siRNA also reduced activation of JNK in response to TGF-beta 1, and a JNK-specific inhibitor decreased both cell migration and MMP-9 expression. Taken together, these results suggest that TGF-beta 1-induced HaCaT cell migration is mediated by MMP-14, which regulates MMP-9 expression via JNK signaling.
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