Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 104, Issue 6, Pages 2241-2247Publisher
WILEY-LISS
DOI: 10.1002/jcb.21782
Keywords
3T3-L1 adipocyte; adipokine; interleukin-1 beta; serum amyloid A3
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Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin(IL)-1 beta was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1 beta in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1 beta significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1 beta-induced SAA3 expression was mediated by nuclear factor-kappa B and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1 beta.
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