Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 22, Issue 11, Pages 5188-5195Publisher
WILEY
DOI: 10.1111/jcmm.13822
Keywords
angiogenesis; inflammation; migration; nanotube formation; proliferation; TNFAIP2
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Funding
- Department of Education, Yunnan Province of China [2016ZZX202]
- National Nature Science Foundation of China [31771516, 81672624, U1602221]
- Diagnosis, Treatment and Transformation Engineering Technology Research Center for Renal Cell Carcinoma of Yunnan Province [2016DNH001]
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TNF-induced protein 2 (TNFAIP2) is a primary response gene of TNF alpha. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF-kappa B, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
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