Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 19, Issue 1, Pages 198-209Publisher
WILEY
DOI: 10.1111/jcmm.12417
Keywords
peroxisome proliferator-activated receptorgene; single-nucleotide polymorphisms; serum lipid level; meta-analysis
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Funding
- National 973 Project of China [2007CB512008]
- Scientific Research Foundation of Shanghai Jiao Tong University School of Medicine [12XJ3008]
- Scientific Research Foundation of Shanghai First People's Hospital [11B24]
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Considerable studies have been carried out to investigate the relationship between the polymorphisms of PPARG (Pro12Ala, C161T and C1431T) and serum lipid levels, but the results were inconclusive. Hence, we conducted a meta-analysis to clarify the association. MEDLINE, EMBASE and the Cochrane Library databases were searched systematically. The subgroup analysis was performed based on ethnicity. Seventy-four studies with 54,953 subjects were included in this meta-analysis. In Pro12Ala, the group with the PP' (C/C genotype) genotype group had lower levels of total cholesterol (TC) (mean difference, MD: -0.02, P<0.00001; I-2=28%), low-density lipoprotein cholesterol (LDL-C) (MD: -0.02, P<0.00001; I-2=30%) and higher levels of triglyceride (TG) (MD: 0.06, P<0.00001; I-2=30%) than the combined PA+AA' (PA = C/G genotype, AA = G/G genotype) genotype group in Asian population, and the group with the PP' genotype had higher levels of TG (MD: 0.07, P<0.02; I-2=67%) than the combined PA+AA' genotype group in non-Asian population. No statistically significant differences in the levels of TC, TG, high-density lipoprotein cholesterol, LDL-C were detected between different genotypes in C161T(Asian or non-Asian) and C1431T(Asian) polymorphisms. This meta-analysis was a renewed and confirmed study to assess the association between PPARG polymorphisms and serum lipid levels in Asian and non-Asian populations. There is a prominent association between Pro12Ala polymorphism and the levels of TC, LDL-C and TG in Asian population. No statistically significant differences in serum lipid levels were detected between different genotypes in C161T and C1431T polymorphisms.
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