Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 18, Issue 8, Pages 1491-1508Publisher
WILEY
DOI: 10.1111/jcmm.12164
Keywords
angiogenesis; computational model; mathematical model; systems biology; multi-scale modelling
Categories
Funding
- National Institutes of Health [R00 HL093219, R01 CA138264, R01 HL101200, F32 CA154213]
- UNCF Merck Science Initiative
- Johns Hopkins University Libraries
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Blood travels throughout the body in an extensive network of vessels - arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels - arterioles, venules and capillaries - can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis - the sprouting of new blood vessels - and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.
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