Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 15, Issue 5, Pages 1071-1074Publisher
WILEY
DOI: 10.1111/j.1582-4934.2011.01325.x
Keywords
telocytes; telopodes; microRNA; laser capture microdissection
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Funding
- European Social Fund
- Romanian Government [POSDRU/89/1.5/S/64153, POSDRU/89/1.5/S/64109]
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Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells.
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