Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 12, Issue 6A, Pages 2263-2280Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00402.x
Keywords
Alzheimer's disease (AD); apoptosis; autophagic cell death (ACD); autophagy; endoplasmic reticulum (ER) stress; excitotoxicity; heat shock proteins (Hsps); Huntington's disease (HD); ischaemia; Parkinson's disease (PD); protein aggregation; ubiquitin-proteasome system (UPS); unfolded protein response (UPR)
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Funding
- National University of Ireland
- Galway Millenium Fund
- Irish Research Council for Science and Engineering Technology
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Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro-survival strategies are discussed.
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