Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 12, Issue 5A, Pages 1548-1550Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00356.x
Keywords
iron; furin; Alzheimer's disease
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The role of iron in the pathogenesis of Alzheimer's disease (AD) is still unclear, despite the evidence that it accumulates in the same brain regions characterized by the amyloid beta peptide (A beta) accumulation. Here we propose that iron directly influences the A beta production through the modulation of furin, a proconvertase involved in the regulation of the alpha-secretase-dependent processing of the amyloid protein precursor (APP).
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