Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 12, Issue 6A, Pages 2407-2415Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00243.x
Keywords
deguelin; HIF-1 alpha; oxygen-induced retinopathy; retinal neovascularization
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Funding
- Basic Research Program of the Korea Science & Engineering Foundation [R01-2004-000-10212-0]
- Ministry of Science and Technology (MOST) [M1064501001-06n4501-00110]
- Korea Science AND Engineering Foundation (KOSEF)
- National Research Foundation of Korea [R01-2004-000-10212-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic retinopa-thy for young age group. ROP still remains as the most serious cause of vision loss in children. We provided that deguelin significantly reduces retinal neovascularization in a mouse model of ROP. Deguelin never affected the transcriptional activity of hypoxia inducible factor (HIF)-1 alpha, however, reduced HIF-1 alpha expression, which led to the decrease of vascular endothelial growth factor expression. Deguelin effectively suppressed endothelial cell proliferation without cytotoxic effect under therapeutic concentration range. In addition, deguelin demonstrated no reduction or retardation in normal retinal development and no retinal toxicity. These data suggest deguelin is a potent inhibitor of retinal neovascularization and may be applied in the treatment of other vasoproliferative retinopathies.
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