Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 12, Issue 5B, Pages 1811-1819Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00483.x
Keywords
microRNA biogenesis; microRNA processing
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Funding
- National Cancer Institute [CA114304-01]
- NATIONAL CANCER INSTITUTE [R21CA114304, R33CA114304] Funding Source: NIH RePORTER
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microRNA (miRNA) is a class of small, noncoding, regulatory RNAs. The similar to 21 nt mature miRNA is processed from larger precursor molecules following a coordinated series of events. In theory, miRNA processing may be regulated at any of these steps. A growing body of evidence has demonstrated various steps in the miRNA biogenesis process for which regulation occurs. RNA editing of miRNA precursors, SNPs or mutations in the miRNA precursors, regulation by RNA binding proteins, alterations in the levels of key processing proteins, as well as a number of unknown mechanisms contribute to the regulation of miRNA processing. This article reviews the available literature on the regulation of miRNA processing that occurs within normal cells, during development or in diseases such as cancer.
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