Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 12, Issue 4, Pages 1416-1419Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00346.x
Keywords
electron tomography; immunonanogold electron microscopy; cell secretion; vesicular transport; eosinophils; inflammation; eosinophil sombrero vesicles (EoSVs)
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Funding
- NHLBI NIH HHS [HL070270, R01 HL070270, R01 HL070270-04] Funding Source: Medline
- NIAID NIH HHS [R01 AI022571, R01 AI020241-22, AI051645, AI022571, R01 AI022571-20, AI033372, R01 AI020241-21A1, AI020241, R01 AI020241-23, R01 AI020241, R01 AI020241-24, R01 AI051645-05, R37 AI020241, R01 AI051645, R01 AI033372] Funding Source: Medline
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Electron tomography (ET) has increasingly been used to understand the complexity of membrane systems and protein-trafficking events. By ET and immunonanogold electron microscopy, we recently defined a route for vesicular transport and release of granule-stored products from within activated human eosinophils, cells specialized in the secretion of numerous cytokines and other proteins during inflammatory responses. Here, we highlight these techniques as important tools to unveil a distinct eosinophil vesicular system and secretory pathway.
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