Journal
JOURNAL OF CELL SCIENCE
Volume 127, Issue 10, Pages 2135-2144Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.093575
Keywords
MLKL; RIPK3; Mitochondria; Necroptosis; Pyroptosis
Categories
Funding
- Royal Society
- European Union
- Biotechnology and Biological Sciences Research Counci
- Royal Society University Research Fellow
- EMBO long-term fellowship
- ALSAC (St. Jude Children's Research Hospital)
- National Institutes of Health. Deposited in PMC
- Biotechnology and Biological Sciences Research Council [BB/K008374/1] Funding Source: researchfish
- BBSRC [BB/K008374/1] Funding Source: UKRI
Ask authors/readers for more resources
Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during embryogenesis, development of the immune system and destruction of damaged cells. The best-studied form of programmed cell death is apoptosis, a process that requires activation of caspase proteases. Recently it has been appreciated that various non-apoptotic forms of cell death also exist, such as necroptosis and pyroptosis. These non-apoptotic cell death modalities can be either triggered independently of apoptosis or are engaged should apoptosis fail to execute. In this Commentary, we discuss several regulated non-apoptotic forms of cell death including necroptosis, autophagic cell death, pyroptosis and caspase-independent cell death. We outline what we know about their mechanism, potential roles in vivo and define outstanding questions. Finally, we review data arguing that the means by which a cell dies actually matters, focusing our discussion on inflammatory aspects of cell death.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available