Journal
JOURNAL OF CELL SCIENCE
Volume 127, Issue 23, Pages 4987-4993Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.158550
Keywords
Acidification; pH regulation; Proton pump; Proton motive; Vacuolar ATPase
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Funding
- Canadian Institutes for Health Research [MOP7075, MOP102474, MOP4665]
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The vacuolar H+-ATPase (V-ATPase) has long been appreciated to function as an electrogenic H+ pump. By altering the pH of intracellular compartments, the V-ATPase dictates enzyme activity, governs the dissociation of ligands from receptors and promotes the coupled transport of substrates across membranes, a role often aided by the generation of a transmembrane electrical potential. In tissues where the V-ATPase is expressed at the plasma membrane, it can serve to acidify the extracellular microenvironment. More recently, however, the V-ATPase has been implicated in a bewildering variety of additional roles that seem independent of its ability to translocate H+. These non-canonical functions, which include fusogenicity, cytoskeletal tethering and metabolic sensing, are described in this Cell Science at a Glance article and accompanying poster, together with a brief overview of the conventional functions of the V-ATPase.
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