Journal
JOURNAL OF CELL SCIENCE
Volume 127, Issue 24, Pages 5127-5137Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.151472
Keywords
Epithelial cells; Adherens junctions; Cytokinesis
Categories
Funding
- Centre National de la Recherche Scientifique (CNRS)
- La Ligue contre le Cancer (Equipe Labellisee)
- National Research Agency (ANR) (Blanc SVSE2 ApiNotch)
- University of Rennes 1 funds
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Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed and stabilized by Ecadherin and catenin proteins linked to the actomyosin cytoskeleton. During development and throughout adult life, epithelia are continuously growing or regenerating, largely as a result of cell division. Although persistence of adherens junctions is needed for epithelial integrity, these junctions are continually remodelled during cell division. In this Commentary, we will focus on cytokinesis, the final step of mitosis, a multiparty phenomenon in which the adherens junction belt plays an essential role and during which a new cell-cell interface is generated between daughter cells. This new interface is the site of intense remodelling, where new adhesive contacts are assembled and cell polarity is transmitted from mother to daughter cells, ultimately becoming the site of cell signalling.
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