Journal
JOURNAL OF CELL SCIENCE
Volume 124, Issue 20, Pages 3441-3449Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.083683
Keywords
Aurora kinase; Mitotic entry; Nutrient; Polo; TOR kinase
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/E002056/1]
- Cancer Research UK [C10888/A11178]
- University of Manchester
- BBSRC [BB/E002056/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E002056/1] Funding Source: researchfish
- Cancer Research UK [11178] Funding Source: researchfish
Ask authors/readers for more resources
The coordination of cell division and growth in response to changes in nutrient supply is mediated by TOR signalling. In fission yeast, increased nutrient provision transiently delays mitotic onset without affecting growth. The result is an increase in cell size at division. We find that this block to cell division relies upon TOR and MAPK signalling and that mitotic entry during recovery from this block is regulated by the Aurora kinase Ark1. We show that Ark1 phosphorylation of polo kinase Plo1 within the linker region between the kinase domain and polo boxes drives Plo1 onto the spindle poles where it promotes mitosis. Interestingly, the use of Ark1 to phosphorylate Plo1 and promote mitotic entry is dependent on the environment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available