Journal
JOURNAL OF CELL SCIENCE
Volume 123, Issue 20, Pages 3447-3455Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.063727
Keywords
Cilia; Modification; Tubulin
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Funding
- National Science Foundation [MBC-033965]
- National Institutes of Health [R01GM089912]
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Microtubules - polymers of tubulin - perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.
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